Supports Chapter 21: Diseases of the heart and blood vessels
An interesting study has just been published which looks at a wide range of possible variables in the formation of the arterial lesions thought to cause heart attacks. The interesting part is that, although all the traditional ‘risk factors’ for heart disease such as cholesterol, HDL, LDL were considered, the factor that really stood out was none of these. It was blood glucose levels – from a ‘healthy’ carbohydrate-based diet, perhaps?
This study is open access so anyone can read the full paper online.
Nunes JPL, Silva JC (2009) Systemic Correlates of Angiographic Coronary Artery Disease. PLoS ONE 4(1): e4322. doi:10.1371/journal.pone.0004322
Coronary angiography allows a direct evaluation of coronary anatomy.
The aim of the present investigation was to search for correlations between the magnitude of coronary artery disease, as assessed by angiography, and a number of systemic parameters.
A group of 116 patients (80 male, 36 female) with coronary heart disease diagnosed by angiography, aged 62.0610.5 years, was the subject of an observational study.
Correlation and linear regression analysis using coronary artery disease burden (CADB - sum of the percentage of the luminal stenosis encountered in all the lesions of the coronary arterial trees) as dependent variable, and age, sex, plasma calcium, phosphorus, magnesium, glucose, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, estimated glomerular filtration rate and body mass index as independent variables, were carried out.
Significant correlation values versus CADB were seen with age (r 0.19, p 0.04), uric acid (r 0.18, p 0.048) and fasting plasma glucose (r 0.33, p,0.001). Linear regression analysis, yielding a global significance level of 0.002, showed a significant value for glucose (p 0.018) and for sex (0.008).
In conclusion, among several systemic parameters studied, plasma glucose was found to be correlated to coronary artery atherosclerosis lesions.