Supports Chapter 1: Trick to treat, Chapter 2: What’s behind the screens? and Chapter 20: Diabetes deceit.
As diabetics are about eight times more likely to suffer a heart attack than the healthy population, not only are they told to eat an unhealthy 'healthy' diet, they are also routinely prescribed the cholesterol-lowering drugs called statins.
Disease of the blood vessels caused by diabetes mellitus represents a significant medical problem that has been firmly established in large clinical trials to be directly related to high glucose levels. At a cellular level, high glucose exposure damages endothelial cells (the cells that line the blood vessels) and inhibits their repair. Needless to say, this is highly undesirable and could account for many of the complications of diabetes.
Glucose does this by inhibiting the 'mevalonate pathway', a series of chemical processes that produce a number of compounds needed for endothelial cell repair.
Cholesterol is also a compound which is manufactured via the mevalonate pathway; it is this pathway that is inhibited by statins.
A brand new study from the University of Sydney, Australia, finds that statins, not surprisingly, which work by blocking not only cholesterol but also the other vital compounds that the body needs, have a similar effect to high levels of glucose.
It would seem foolhardy, therefore, to continue the practice of putting all (or indeed any) diabetics on statins.
Mather A, et al. High glucose induced endothelial cell growth inhibition is associated with an increase in TGFβ1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway. Int J Biochem Cell Biol (2008),